- Principal Investigator -

Gang Cheng
Associate Professor
email: gancheng@uic.edu
Phone: 312-413-7672
Fax: 312-996-0808
Office: Chemical Engineeirng Building 203
University of Illinois at Chicago, Chicago, IL 60607


  1. Huifeng Wang, Daniel Edward Christiansen, Shafigh Mehraeen, Gang Cheng*, Winning the fight against biofilms: First six-month study showing no biofilm formation on zwitterionic polyurethanes, Chemical Science 2020, DOI: 10.1039/C9SC06155J Link
  2. Meng-Hsuan Lin, Shafigh Mehraeen, Gang Cheng, Cory Rusinek, and Brian P. Chaplin*, Bacteria poration on modified boron-doped diamond electrode surfaces induced by divalent cation chelation, Environ. Sci.: Water Res. Technol. 2020, DOI: 10.1039/C9EW01108K. Link
  3. Meng-Hsuan Lin, Shafigh Mehraeen, Gang Cheng, Cory Rusinek, and Brian P. Chaplin*, Role of Near-Electrode Solution Chemistry on Bacteria Attachment and Poration at Low Applied Potentials, Environ. Sci. Technol. 2020, 54, 1, 446-455. Link
  4. Mingyang Li, Fang Cheng*, Haoqiang Li, Weiwei Jin, Chen Chen, Wei He, Gang Cheng, Qing Wang, Site-Specific and Covalent Immobilization of His-Tagged Proteins via Surface Vinyl Sulfone–Imidazole Coupling, Langmuir 2019, 35, 50, 16466-16475. Link
  5. Suyuan Zhou, Tao Zhu, Luyao Zheng, Wenzhan Xu, Lei Liu, Cheng, G.*, Jie Zheng*, and Xiong Gong*, A zwitterionic polymer as an interfacial layer for efficient and stable perovskite solar cells, RSC Advances 2019, 9, 30317-30324. Link
  6. Qu, Xinjian; Hu, Yang; Wang, Huifeng; Song, Haiqing; Young, Megan; Xu, Fujian; Liu, Ying; Cheng, G.*, Biomimetic dextran-peptide vectors for efficient and safe siRNA delivery, ACS Applied Biomaterials 2019, DOI: 10.1021/acsabm.8b00714. Link
  7. Chen Xu, Yanzhenzi Zhang, Ke Xu, Jing-Jun Nie, Bingran Yu, Sijin Li, Cheng, G, Yulin Li, Jie Du, and Fujian Xu*, Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection, Nature communications 2019, 10, Article number: 3184. Link
  8. Yang Hu; Huifeng Wang; Haiqing Song, Megan Young; Yaqian Fan, Fu-Jian Xu, Xijian Qu,Xia Lei, Ying Liu, Cheng, G.*, The critical roles of histidine residue in peptide-grafted dextran vector for efficient and high-loading gene delivery, Biomaterials science 2019, 10.1039/C8BM01341A. Link
  9. Yu Qi; Haiqing Song; Haihua Xiao; Cheng, G.; Bingran Yu, Fujian Xu*, Fluorinated Acid-Labile Branched Hydroxyl-Rich Nanosystems for Flexible and Robust Delivery of Plasmids, Small 2018, 14(42):e1803061. Link
  10. Huifeng Wang; Yang Hu; Dylan Lynch; Megan Young; Shengxi Li; Hongbo Cong; Fu-Jian Xu; Cheng, G.*, Tunable Surface and Bulk Properties of Zwitterionic Polyurethane, ACS Applied Materials & Interfaces 2018, DOI 10.1021/acsami.8b10450. Link
  11. Shengxi Li; Huifeng Wang; Megan Young; Fujian Xu; Cheng, G.*; Hongbo Cong, Properties of electro-polymerized dopamine and its analogues, Langmuir 2018, 10.1021/acs.langmuir.8b01444. Link
  12. Lizhi Song; Xin Zhou; Xiaoguang Dai; Ranran Wang; Cheng, G.; Nana Zhao; Fujian Xu*, Self-destructible polysaccharide nanocomposites with unlockable Au nanorods for high-performance photothermal therapy, NPG Asia Materials 2018, 10, 509–521. Link
  13. Chen-Jung Lee; Huifang Wang; Megan, Young; Dylan Lynch, Hongbo Cong; Cheng, G.*, Structure-function study of Poly(sulfobetaine 3,4-ethylenedioxythiophene) (PSBEDOT) and its derivatives, Acta Biomaterilia 2018, 75, 161-170. Link
  14. Hai-Qing Song; Yu Qi; Rui-Quan Li; Cheng, G.; Nana Zhao*; Fu-Jian Xu*, High-Performance Cationic Polyrotaxanes Terminated with Polypeptides as Promising Nucleic Acid Delivery Systems, Polymer Chemistry 2018, 9, 2281-2289. Link
  15. Liu; J. Y.; Li, Y.; Hu, Y.; Cheng, G.; Ye, E. Y.; Shen, C. A.; Xu, F. J.* Hemostatic porous sponges of cross-linked hyaluronic acid/cationized dextran by one self-foaming process, Materials Science & Engineering C-Materials for Biological Applications 2018, 83: 160-168. 0.1016/j.msec.2017.10.007.g. Link
  16. Haiyan Wu; Chen-Jung Lee; Huifeng Wang; Yang Hu; Megan Young; Hongbo Cong*; Cheng, G.*, Highly Sensitive and Stable Zwitterionic Poly(Sulfobetaine 3,4-Ethylenedioxythiophene) (PSBEDOT) Glucose Biosensor in Complex Media, Chemical Science 2018, 9, 2540 - 2546. Link
  17. Lee, Chen-Jung; Haiyan Wu; Yang Hu; Megan, Young; Dylan Lynch; Huifang Wang; Fujian Xu; Hongbo Cong,*; Cheng, G.*, Ionic conductivity in polyelectrolyte hydrogels, ACS Applied Materials & Interfaces 2018, 10 (6), 5845–5852. Link
  18. Shengxi Li; Zhencheng Ren; Yalin Dong; Chang Ye; Cheng, G.; Hongbo Cong, Enhanced Pitting Corrosion Resistance of 304 SS in 3.5 wt% NaCl by Ultrasonic Nanocrystal Surface Modification, ECS Journal of Solid State Science and Technology 2017, 164(12), C682-C689. Link
  19. Wang, H.; Cheng, F.; He, W.; Zhu, J.; Cheng, G.; Qu, J., Poly(ethylene) glycol hydrogel based on oxa-Michael reaction: Precursor synthesis and hydrogel formation, Biointerphases 2017, 12(2), 10.1116/1.4984305. Link
  20. Wang, H. Q.; Cheng, F.; Shen, W.; Cheng, G.; Zhao, J.; Peng, W.; Qu, J. P., Amino acid-based anti-fouling functionalization of silica nanoparticles using divinyl sulfone, Acta Biomater 2016, 40, 273-281. Link
  21. Wang H.F.; Wu, H.Y.; Lee, J.C.; Lei, X.; Xu, F.J.; Cheng, G.*, pH-sensitive Poly(histidine methacrylamide), Langmuir 2016, 32 (25), 6544–6550. Link
  22. Wang, H.Q.; Cheng, F.*; Shen, W.; Cheng, G.; Zhao, J.; Peng, W.; Qu, J.P., Amino acid-based anti-fouling functionalization of silica nanoparticles using vinyl sulfone chemistry, Acta Biomaterialia 2016, doi:10.1016/j.actbio.2016.03.035. Link
  23. Han, Y.; Wu, H. Y.; Liu, F.; Cheng, G.*; Zhe, J.*, A Multiplexed Immunoaggregation Biomarker Assay Using a Two-stage Micro Resistive Pulse Sensor, Biomicrofluidics 2016, 10, 024109. Link
  24. Han, Y.; Wu, H. Y.; Liu, F.; Cheng, G.*; Zhe, J.*, A Micro Resistive Pulse Immunosensor for Label-free Pathogen Measurement, Lab on a Chip 2016, 16, 773-779. Link
  25. Yuan, W.H.; Xu, C.; Zhao, Y.; Yu, B.R.;* Cheng, G.; Xu, F.J.*, Well-defined protein-based supramolecular nanoparticles with excellent MRI abilities for multifunctional delivery systems, Advanced Functional Materials 2016, DOI: 10.1002/adfm.201504980. Link
  26. Wu, H.Y.; Wang H.F.; Cheng, F.; Xu, F.J.; Cheng, G.*, Synthesis and Characterization of enzyme-degradable zwitterionic dextran hydrogel, RSC Advances 2016, 6, 30862 - 30866. Link
  27. Cao B.; Lee, J. C.; Zeng, Z. P.; Cheng, F.; Xu, F. J.; Cong, H. B.*; Cheng, G.*, Electroactive Zwitterionic Poly(sulfobetaine 3,4-ethylenedioxythiophene) (PSBEDOT) with Controllable Antimicroibal and Antifouling Properties, Chemical Science 2016, 7, 1976-1981. Link
  28. Lee, J. C.; Wu, H.Y.; Tang, Q.; Cao, B.; Wang, H. F.; Cong, H. B.; Zhe, J.; Xu, F. J.; Cheng, G.*, The structure-function relationships of a tertiary amine-based polycarboxybetaine, Langmuir 2015, 31 (36), 9965–9972. Link
  29. Xu, F. J.*; Zhao, Y. ; Duan, S.; Yu, B. R.; Liu, F. S.; Cheng, G., Gd(III) ions-chelated supramolecular assemblies composed of PGMA-based polycations for effective biomedical applications, NPG Asia Materials 2015, doi:10.1038/am.2015.67. Link
  30. Hu, H.; Yuan, W.; Liu, F.S.; Cheng, G.; Xu, F.J.*; Ma, J., Redox-Responsive Polycation-Functionalized Cotton Cellulose Nanocrystals for Effective Cancer Treatment, ACS Applied Materials & Interfaces 2015, 7 (16), pp 8942–8951. Link
  31. Tang, Q.; Lei, X.; Cao, B.; Sun, B. B.; Zhang, Y. Q.; Cheng, G.*, Naturally derived dextran-peptide vector for microRNA antagomir delivery, RSC Advances 2015, 5, 28019 - 28022. Link
  32. Wu, H. Y.; Han, Y.; Yang, X.; Chase, G. G.; Tang, Q., Lee, J. C.; Cao, B.; Zhe, J.*; Cheng, G.*, A versatile microparticle-based immunoaggregation assay for macromolecular biomarker detection and quantification, PLOS ONE 2015, 10(2):e0115046. Link
  33. Cao, B.; Tang, Q.; Li, L. L.; Lee, C. J.; Wang, H.; Zhang, Y. Q.; Castaneda, H.*; Cheng, G.*, Integrated Zwitterionic Conjugated Poly(carboxybetaine thiophene) as a New Biomaterial Platform, Chemical Science 2015, 6 (1), 782 - 788. Link
  34. Chen, Y. J.; Tang, Q.; Senko, J.; Cheng, G.; Newby, B. M.; Castaneda-Lopez, H.; Ju, L. K.*, Long-term survival of Desulfovibrio vulgaris on carbon steel and associated pitting corrosion, Corrosion Science 2014, 90, 89–100. Link
  35. Xue, J. S.; Yin, L. Y.; Xu, Y.; Li, Y. Y.; Zalzala, M.; Cheng, G.; Zhang, Y. Q.*, Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, PLOS ONE 2014, 9(10): e109663. Link
  36. Wang, H.; Ju, L. K.; Castaneda-Lopez, H.; Cheng, G.; Newby, B. M.*, Corrosion of carbon steel C1010 in the presence of iron oxidizing bacteria Acidithiobacillus ferrooxidans, Corrosion Science 2014, DOI: 10.1016/j.corsci.2014.09.005. Link
  37. Han, Y.; Wu, H. Y.; Liu, F.; Cheng, G.*; Zhe, J.*, Label-free biomarker assay in a micro resistive pulse sensor via immunoaggregation, Analytical Chemistry 2014, 86 (19), pp 9717–9722. Link
  38. Cao, B.; Tang, Q.; Cheng, G.*, Recent advances of zwitterionic carboxybetaine materials and their derivatives, Journal of Biomaterials Science: Polymer Edition 2014, doi: 10.1080/09205063.2014.927300. Link
  39. Tang, Q.; Cao, B.; Lei, X.; Sun, B. B.; Zhang, Y. Q.; Cheng, G.*, Dextran-peptide hybrid for efficient gene delivery, Langmuir 2014, 30 (18), 5202–5208. Link
  40. Cao, B.; Li, L. L.; Wu, H. Y.; Qiong, T.; Sun, B. B.; Dong, H.; Zhe, J.; Cheng, G.*, Zwitteration of dextran: a facile route to integrate antifouling, switchability and optical transparency into natural polymers, Chemical Communications 2014, 50 (24), 3234 - 3237. Link
  41. Liu, Q. S.; Li, W. C.; Singh, A.; Cheng, G.; Liu, L. Y.*, Two amino acid - based superlow fouling polymers: poly(lysine methacrylate) and poly(ornithine methacrylate), Acta Biomaterialia 2014, 10 (7), 2956–2964.Link
  42. Tang, Q.; Cao, B.; Cheng, G.*, Co-delivery of small-interfering RNA using a camptothecin prodrug as the carrier, Chemical Communications 2014, 50, (11), 1323 - 1325. Link
  43. Cao, B.; Li, L. L.; Tang, Q.; Cheng, G.*, The impact of structure on elasticity, switchability, stability and functionality of an all-in-one carboxybetaine elastomer, Biomaterials 2013, 34 (31), 7592–7600. Link
  44. Cao, B.; Tang, Q.; Li, L. L.; Humble, J.; Wu, H. Y.; Liu, L. Y.; Cheng, G.*, Switchable antimicrobial and anti-fouling hydrogels with an enhanced mechanical property, Advanced Healthcare Materials 2013, 2, 1096–1102.Link
  45. Tang, Q.; Cao, B.; Wu, H. Y.; Zhang, Y. Q.; Cheng, G.*, Cholesterol-peptide hybrids to form liposome-like vesicles for gene delivery, PLOS ONE 2013. Link
  46. Zhao, C.; Li, X.S.; Li, L. Y.; Cheng, G.; Gong, X.; Zheng, J., Dual functionality of antimicrobial and antifouling of Poly(N-hydroxyethylacrylamide)/Salicylate hydrogels, Langmuir 2013, ASAP. Link
  47. Tang, Q.; Cao, B.; Wu, H. Y.; Cheng, G.*, Selective gene delivery to cancer cells using an integrated cationic amphiphilic peptide, Langmuir 2012, 28, (46), 16126-16132. Link
  48. Beltran, A.; Cao, B.; Cheng, G.*, Jana, S.*; Espe, M.; Lama, B., New antifouling silica hydrogel, Langmuir 2012, 28, (25), 9700-9706. Link
  49. Yang, J.-C.; Zhao, C.; Hsieh, I. F.; Subramanian, S.; Liu, L.; Cheng, G.; Li, L.; Cheng, S. Z. D.; Zheng, J., Strong resistance of poly (ethylene glycol) based L-tyrosine polyurethanes to protein adsorption and cell adhesion. Polym. Int. 2012, 61, (4), 616-621. Link
  50. Cheng, G.; Mi, L.; Cao, Z.; Xue, H.; Yu, Q.; Carr, L.; Jiang, S., Functionalizable and Ultrastable Zwitterionic Nanogels. Langmuir 2010, 26, (10), 6883-6886. Link
  51. Carr, L.; Cheng, G.; Xue, H.; Jiang, S., Engineering the Polymer Backbone To Strengthen Nonfouling Sulfobetaine Hydrogels. Langmuir 2010, 26, (18), 14793-14798. Link
  52. Cheng, G.; Xue, H.; Li, G.; Jiang, S., Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean. Langmuir 2010, 26, (13), 10425-10428. Link
  53. Cao, Z.; Yu, Q.; Xue, H.; Cheng, G.; Jiang, S., Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks. Angew. Chem. Int. Ed. 2010, 49, (22), 3771-3776. Link
  54. Mi, L.; Bernards, M. T.; Cheng, G.; Yu, Q.; Jiang, S., pH responsive properties of non-fouling mixed-charge polymer brushes based on quaternary amine and carboxylic acid monomers. Biomaterials 2010, 31, (10), 2919-2925. Link
  55. Cheng, G.; Li, G.; Xue, H.; Chen, S.; Bryers, J. D.; Jiang, S., Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation. Biomaterials 2009, 30, (28), 5234-5240. Link
  56. Zheng Zhang, Timothy Chao, Lingyun Liu, Cheng, G., Buddy D Ratner, Shaoyi Jiang, Zwitterionic hydrogels: an in vivo implantation study. Journal of Biomaterials Science, Polymer Edition 2009, 20, (13), 1845-1859. Link
  57. Zhang, Z.; Chao, T.; Liu, L.; Cheng, G.; Ratner, B. D.; Jiang, S., Zwitterionic Hydrogels: an in Vivo Implantation Study. Journal of Biomaterials Science, Polymer Edition 2009, 20, (13), 1845-1859. Link
  58. Vaisocherová, H.; Zhang, Z.; Yang, W.; Cao, Z.; Cheng, G.; Taylor, A. D.; Piliarik, M.; Homola, J.; Jiang, S., Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma—Material selection and protein immobilization optimization. Biosens. Bioelectron. 2009, 24, (7), 1924-1930. Link
  59. Cheng, G.; Xue, H.; Zhang, Z.; Chen, S.; Jiang, S., A Switchable Biocompatible Polymer Surface with Self-Sterilizing and Nonfouling Capabilities. Angew. Chem. Int. Ed. 2008, 47, (46), 8831-8834. (Highlighted by Science and Nature Materials) Link
  60. Zhang, Z.; Vaisocherová, H.; Cheng, G.; Yang, W.; Xue, H.; Jiang, S., Nonfouling Behavior of Polycarboxybetaine-Grafted Surfaces: Structural and Environmental Effects. Biomacromolecules 2008, 9, (10), 2686-2692. Link
  61. Li, G.; Cheng, G.; Xue, H.; Chen, S.; Zhang, F.; Jiang, S., Ultra low fouling zwitterionic polymers with a biomimetic adhesive group. Biomaterials 2008, 29, (35), 4592-4597. Link
  62. Zhang, Z.; Cheng, G.; Carr, L. R.; Vaisocherová, H.; Chen, S.; Jiang, S., The hydrolysis of cationic polycarboxybetaine esters to zwitterionic polycarboxybetaines with controlled properties. Biomaterials 2008, 29, (36), 4719-4725. Link
  63. Yang, W.; Chen, S.; Cheng, G.; Vaisocherová, H.; Xue, H.; Li, W.; Zhang, J.; Jiang, S., Film Thickness Dependence of Protein Adsorption from Blood Serum and Plasma onto Poly(sulfobetaine)-Grafted Surfaces. Langmuir 2008, 24, (17), 9211-9214. Link
  64. Vaisocherová, H.; Yang, W.; Zhang, Z.; Cao, Z.; Cheng, G.; Piliarik, M.; Homola, J. i.; Jiang, S., Ultralow Fouling and Functionalizable Surface Chemistry Based on a Zwitterionic Polymer Enabling Sensitive and Specific Protein Detection in Undiluted Blood Plasma. Anal. Chem. 2008, 80, (20), 7894-7901. Link
  65. Li, G.; Xue, H.; Cheng, G.; Chen, S.; Zhang, F.; Jiang, S., Ultralow Fouling Zwitterionic Polymers Grafted from Surfaces Covered with an Initiator via an Adhesive Mussel Mimetic Linkage. The Journal of Physical Chemistry B 2008, 112, (48), 15269-15274. Link
  66. Bernards, M. T.; Cheng, G.; Zhang, Z.; Chen, S.; Jiang, S., Nonfouling Polymer Brushes via Surface-Initiated, Two-Component Atom Transfer Radical Polymerization. Macromolecules 2008, 41, (12), 4216-4219. Link
  67. Cheng, G.; Zhang, Z.; Chen, S.; Bryers, J. D.; Jiang, S., Inhibition of bacterial adhesion and biofilm formation on zwitterionic surfaces. Biomaterials 2007, 28, (29), 4192-4199. Link
  68. Shapir, N.; Cheng, G.; Sadowsky, M. J.; Wackett, L. P., Purification and Characterization of TrzF: Biuret Hydrolysis by Allophanate Hydrolase Supports Growth. Appl. Environ. Microbiol. 2006, 72, (4), 2491-2495. Link
  69. Cheng, G.; Shapir, N.; Sadowsky, M. J.; Wackett, L. P., Allophanate Hydrolase, Not Urease, Functions in Bacterial Cyanuric Acid Metabolism. Appl. Environ. Microbiol. 2005, 71, (8), 4437-4445. Link

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